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Chronic
sinusitis infections are commonly known
to be of a polymicrobial nature. A single
oral agent usually does not have the
capability of covering all the organisms
involved in chronic sinusitis. In addition
oral agents may fail due to less than
optimal concentration of medications that
can be achieved in the bloodstream. This
mainly happens because of decreased
absorption in the gastrointestinal tract.
Decreased absorption can occur because of
the co-administration of other oral agents,
interaction with certain food and drink
groups and illness. The reduced
concentration of medicine via oral agents
has difficulty attacking the infection when
located in the bone surrounding the sinus
cavities.
Intravenous
antibiotics can overcome many of the
drawbacks involving oral agents. The
concentration of antibiotic in many cases is
more stable. The antibiotic is not affected
by variables in the gastrointestinal tract
because it bypasses and directly enters the
bloodstream.
Absorption
problems are minimized. Since some of the
infection is in the surrounding bone a
higher concentration of medicine is
necessary. Intravenous induction will
increase the concentration and can be
sustained over longer periods of time. The
use of multiple antibiotics at the same time
helps to insure a broader spectrum of
action, thus attacking many forms of
bacterial infections simultaneously.
There
is a certain population of patients who will
find major relief to chronic sinusitis
solely through the administration of
antibiotics via intravenous methods. Other
patients still needing surgery will find
that IV antibiotics will greatly reduce the
inflammation in the sinuses. This will allow
the surgeon cleaner access to perform his
tasks. Post surgical recovery has proven
easier on these patients.
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